Total knee replacement is an effective treatment for patients with end stage osteoarthritis of the knee, but a significant proportion of patients will be challenged with pain during their recovery. The Early Pain Intervention after Knee replacement trial will identify patients having difficulties with their early recovery (3 months) through the AOA National Joint Replacement Registry, assess those patients’ needs, and offer a tailored multidisciplinary program to address issues with their recovery. The trial has been funded for approx.. $4m by the NHMRC, MRFF, and Ramsay Hospital Research Foundation.