Opioid usage and dependence is a common problem after injury and orthopaedic surgery. The Reducing Opioids After Discharge trial will test the effectiveness of an opioid vs. no opioid analgesia regime, in patients after routine fracture fixation, using a placebo controlled superiority randomised trial design.

The TAP-ON trial is a pilot randomised study comparing tapentadol and oxycodone for postoperative pain management. The primary aim is to explore whether tapentadol is associated with a lower risk of opioid dependency following surgery compared to oxycodone.